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When Myelin Is The Cause, Might Nicotine Be the Cure?

January 2007

The development, maintenance, and repair of myelin is the single most important factor affecting cognition and behavior, according to a UCLA neurology professor who has collected extensive data on the nerve insulator. In an article to be published in an upcoming issue of Biological Psychiatry, George Bartzokis, MD, asserts that myelin may be the universal cause or contributor to a wide range of neuropsychological brain disorders, from autism to Alzheimer’s disease. Dr. Bartzokis, who directs the UCLA Memory Disorders and Alzheimer’s Disease Clinic in Los Angeles, suggests that using noninvasive imaging technology to view the miles of myelin in the brain as it grows and breaks down throughout a human life cycle may offer insights leading to the development of new treatments for brain disorders. Nicotine, which studies have suggested enhances the growth and maintenance of myelin, could be one such novel treatment.

In some of the first research to approach brain disorders from a myelin-centered point of view, Dr. Bartzokis studied the effects of cholinergic treatments, including acetylcholinesterase inhibitors (AChEIs) that are used to improve a neuron’s synaptic signaling in people with diseases such as Alzheimer’s. Some data suggest that such treatments may even modify or slow the progression of Alzheimer’s as well as other diseases.

Nicotine, Age, and Disease

Dr. Bartzokis hypothesizes that cholinergic stimulation at neuronal synapses affects the myelination process throughout brain development in the course of a human’s lifetime.He found in clinical trials that cholinergic treatment protects brain cells, while postmortem and imaging data have shown cholinergic receptor changes during brain development and degeneration. Trials have also revealed epidemiologic evidence that nicotine from tobacco may have a protective effect on degenerative diseases of old age and younger psychiatric populations. Cholinergic treatments have also shown efficacy in the aging process and age-related neurodegenerative diseases such as Alzheimer’s disease, as well as some neurodegenerative diseases like autism and ADHD.

According to Dr. Bartzokis, myelination development resembles an inverted “U” over the course of a lifetime, with increasing myelin development peaking in middle age and breaking down and declining in later years. Following the analogy of the Internet, Dr. Bartzokis says the “connectivity” provided by myelination increases speed by 10-fold and decreases refractory time by 34-fold. Thus, myelination increases the “bandwidth,” or processing capacity, of our brain’s Internet by 340-fold and is “indispensable for developing our uniquely elaborate higher cognitive functions.”

Different cortical regions myelinate at different ages, with later-myelinating oligodendrocytes growing increasingly more complex as we age. Irregular development during the most complex stages of the myelination process contributes to several of the neuropsychiatric disorders that tend to manifest in the early years. These disorders—eg, autism, ADHD, schizophrenia, mood disorders, addictions—are defined by overlapping cognitive and behavioral symptom clusters.

According to Dr. Bartzokis, healthy individuals with normal myelin development typically lose 45% of their myelinated fiber length when they reach the degeneration phase in adulthood. This change in the brain may cause progressive losses of memory and cognitive functions, as well as mild to severe behavioral changes.

The loss of myelin and its components such as sulfatide, myelin basic protein, and cholesterol begins early in the development of Alzheimer’s disease, well before diagnosis of dementia or mild cognitive impairment. The myelin breakdown process is further modified by risk factors such as the presence of APOE ε4 or environmental factors such as a head trauma.

Nicotine's Effect on Myelination and Repair

Recent research has unveiled some surprising findings on the influence of nicotine on myelination and the aging process. Direct nicotinic stimulation associated with smoking has been shown to increase nicotinic receptors in the late myelinating frontal and temporal intracortical regions. Unlike most agonists, nicotine causes an up-regulation of its receptors and has been shown to accelerate brain function recovery when white matter is damaged.

Nicotine dependence is common among people with psychiatric disorders. Some researchers have suggested the high prevalence of nicotine use among the psychiatric population represents an unconscious effort to “self-medicate.” Research on proteins has suggested that nicotine may marginally increase the expression of myelin proteins; other addictive drugs (eg, cocaine, alcohol) along with developmental diseases (eg, schizophrenia, bipolar disorder, depression) show a decrease of these proteins.

Other research has found an association between nicotinic stimulation and protective effects in schizophrenia and autism, where cortical myelination deficits have been documented. While nicotine has well-known negative effects on overall health, smoking during later years is also associated with a reduced likelihood of the development of degenerative conditions like Alzheimer’s and Parkinson’s diseases. Using the myelin-centered model, the apparent beneficial aspects of smoking on brain disorders can be attributed to nicotine’s stimulation of oligodendrocyte precursors. Dr. Bartzokis believes that nicotine, delivered through a patch, not through smoking cigarettes, should be studied for its efficacy in promoting the growth and maintenance of myelin, and that AChEIs “deserve much closer scrutiny” as a therapy for the prevention of both developmental and degenerative brain disorders.

—Kathlyn Stone

Suggested Reading
Bartzokis G. Acetylcholinesterase inhibitors may improve myelin integrity. Biol Psychiatry. 2006 Oct 26; [Epub ahead of print].
Bartzokis G, Lu PH, Mintz J. Quantifying age-related myelin breakdown with MRI: novel therapeutic targets for preventing cognitive decline and Alzheimer’s disease. J Alzheimers Dis. 2004;6(6 suppl):S53-S59.
Doody RS, Geldmacher DS, Gordon B, et al. Open-label, multicenter, phase 3 extension study of the safety and efficacy of donepezil in patients with Alzheimer disease. Arch Neurol. 2000;58:427-433.
Morens DM, Grandinetti A, Reed D, et al. Cigarette smoking and protection from Parkinson’s disease: false association or etiologic clue? Neurology. 1995;45:1041-1051.

http://www.neuropsychiatryreviews.com/07jan/myelin.html

Overview Of Amyotrophic Lateral Sclerosis (ALS)

I. Physiological Considerations

Amyotrophic lateral sclerosis is defined as a degenerative disease of the pyramidal tract and lower motor neurons, characterized by motor weakness and the spastic condition of the limbs associated with muscular atrophy, fibrillary twitching, and final involvement of nuclei in the medulla. It is one of a group of diseases of the motor system of the body, the etiology of which is and continues to be a mystery from the medical standpoint.

The single case included in this file, a 33-year-old man, had symptoms consistent with this definition. His walk was slow and unsteady and he needed crutches. His muscles were twitching and one arm was beginning to atrophy.

In the readings, amyotrophic lateral sclerosis is treated much in the same manner as multiple sclerosis, and the readings give a similar cause in both conditions.

Physiologically, it appears that some factor influences the body's ability to assimilate certain properties through the intestinal tract. In this reading these primary causes are not clarified. Apparently they have something to do with what Cayce in this instance calls karma. In any event, he pictures the lack of assimilation as creating a deficient of those substances in the bloodstream which will, when they are carried throughout the system, help to replenish and rebuild the nerve muscle forces which are affected. He sees a necessity for constant rebuilding or regenerating of the cells throughout the body. The nerve cells controlling muscular activity are no exception and he indicates that the lack is so small that it takes a long period of time for disease to manifest.

In the cases multiple sclerosis, the lack was gold. It seems reasonable to assume that here we are also dealing with a lack of gold assimilated in the normal manner through the intestinal tract through those areas that he often pointed out as being primary in these instances - the lacteals.
The primary deficiency apparently causes, then, a gradual deterioration of anterior horn cells, which then results in deficiency in nerve energies that creates the muscular atrophy. Perhaps this lack contributes to the already present inability of the assimilatory system, by hastening the progress of the disease. The readings described it in one place as a lack of stamina in the nerve and muscle forces of the extremities.

II. Rationale of Therapy

In discussing therapy from this single case, the rationale should be explored to some extent. Much information can be derived from the multiple sclerosis file since Cayce saw so much relationship between the two diseases.

Cayce suggested that, because the disease is of karmic origin, attitudes must be definitely decided upon by the individual - not merely assumed - as to the activities toward divine influences in the body. Where karmic influences are present, Cayce always suggested that attitudes must be definitely changed or no therapeutic results would be seen. He said, "The attitude to be taken should be not merely to be good but to be good for something. The expression of life is of the Divine. The Divine is that influence or force called God. Use same, do not abuse same." (5019-1)

Thus we would see the necessity of mental activity bringing about a change before the physical application of therapy is begun, and this particular portion must be emphasized in each case. One directing the therapy can often not properly assess any changes, but the individual who is ill will know within himself and must face the truth of the statement as seen here in the readings.
Primarily because of the deficiency of gold, the wet cell appliance is used to bring cleansing and healing forces to the body "by the radial activity of the low electrical forces." (5019-1) The gold, then, is given by mouth. It seems reasonable to assume, although not definitely stated in this reading, that gold should be introduced by means of the wet cell appliance in most cases (or perhaps it would have been suggested in a later reading for this particular case had he received a second reading). This would require the clinical appraisal of the condition by the attending physician, and after a two-month period, if there is not progressive improvement, the gold should replace the Atomidine and camphor through the appliance and the Atomidine might then be given by mouth.

In order to introduce at this point a better understanding of the disease process, a complete copy of reading 907-1 follows this commentary. This is on multiple sclerosis specifically but, as already mentioned, probably has a strong bearing on the etiology of amyotrophic lateral sclerosis.

III. Suggested Therapeutic Regimen

Therapy could be divided into five parts, as follows:

1. First things first - mental attitudes
2. Wet cell appliance
3. Massage
4. Gold taken orally
5. Diet

In caring for one's attitudes, not enough can be said. Read Deuteronomy 30 and Exodus 19:5. Then apply these to your life and thinking. Cayce suggested these particularly in all those cases where the trouble was deep-set, and was often seen in association with karma and its physical consequences.

The wet cell with the regular charge was recommended. Two solution jars are to be used: one with Atomidine, one ounce; and distilled water, two ounces. The second contains three ounces of spirits of camphor. These should be alternated, the camphor being used with the attachment at the brachial axis or at the second-third dorsal area of the spine one day; and the Atomidine solution at the fourth lumbar area or the lumbar axis, as Cayce described it, the next day.
Massage should be done gently but thoroughly after the wet cell treatment for a period of 30 to 45 minutes. It should concentrate on the spinal areas but should start at the toes and proceed upward, including all extremities. The sciatic center, the lumbar axis, and the brachial center should be attended to especially, using a mixture of olive oil (two ounces), peanut oil (two ounces), and lanolin (1/4 ounce, melted).

Every third day, one drop of each of the following solutions should be added to 1/2 glass of water and taken immediately: gold chloride solution, one grain per ounce of distilled water; and bromide of soda solution, two grains per ounce of distilled water.

The diet should be low in carbohydrates, and there should be nothing in it containing alcohol. An alkaline-forming diet should be followed rather consistently.

As mentioned earlier, it would be wise to incorporate into the treatment some of the information found in the more extensive Circulating Files on multiple sclerosis. Most often gold chloride was given via the wet cell appliance. In some instances it was also taken orally. Thus, after two months, if regular improvement is not noted, the gold chloride should be started in the solution jar by means of the wet cell appliance. In this instance the attachment of the copper plate should be at the ninth and tenth dorsals in the spine one day, and at the fourth lumbar the next day. When this is begun, Atomidine should be given by mouth in a series that would be best suited to the individual. This would be up to the clinical judgment of the physician. Atomidine has been used in doses of one drop per day for five days, then left off for a period of time, then taken again. It has been given one drop a day for five days, then four drops a day for five days, and then five drops a day for five days. Then it would be left off for a period of one to three weeks, then resumed in the same manner. It has been given beginning with two drops the first day, three drops the second, and so forth on up to ten drops on the ninth day. Then it is decreased one drop per day until the original dose of two drops is reached. Then a rest of several days and the procedure is repeated.

As all of these factors are brought together into a course of therapy, it must be understood that they need to be followed for a long period of time in order to achieve proper results. In nerve lesions and rebuilding of nerve tissue, it is only reasonable to assume that a period of time somewhere between one and three to five years would probably be involved in such a case.

With the rather distressing prognosis to be found in this particular disease, there would be no reason to cease using a program that is constructive in its approach.

"Do these, as we have indicated... Not as rote, but knowing that within self must be found that which may be awakened to the building of that necessary for the body, mentally and physically and spiritually, to carry its part in this experience. For the application of any influence must have that which is of awakening of the activative forces in every atom, every cell of the divine awakening of the activative forces in every atom, every cell of a living body." (726-1)

[Note: The preceding overview was written by William A. McGarey, M.D. and is excerpted from the Physician's Reference Notebook, Copyright © 1968 by the Edgar Cayce Foundation, Virginia Beach, VA.]

Energy Medicine Appliances Used in Meridian Institute Research Projects

http://www.meridianinstitute.com/radwc1.htm

Energy Medicine Appliances Used
in Meridian Institute Research Projects

[Note: This page contains a description of two electrotherapeutic devices researched by the Meridian Institute. The following excerpt comes from a book entitled, The Radial Appliance and Wet Cell Battery: Two Electrotherapeutic Devices Recommended by Edgar Cayce written by David McMillin, M.A. and Douglas G. Richards, Ph.D. Copyright © 1994; used with permission; all rights reserved.]

BASIC DESCRIPTION OF THE RADIAL APPLIANCE AND WET CELL BATTERY

Electrotherapy is a fundamental therapeutic modality in the readings of Edgar Cayce. Cayce's explanation of the importance of electricity in healing is that the body itself is an intricate electrical system. Illness is often associated with imbalances or incoordination in the energy patterns of the body. Treatment is aimed at correcting imbalance in the body so that the body's own natural healing processes can bring coordination and regeneration to the system.

Since many forms of electrotherapy were available during Edgar Cayce's career as a psychic diagnostician, he made use of a wide variety of commercial appliances and devices. Yet by far, he most often recommended two appliances which were not part of mainstream medical practice. In fact, the commercial manufacture and distribution of the Radial Appliance and Wet Cell Battery were initiated and sustained through the information provided in the Cayce material itself. Modern versions of these appliances are still evolving in their design and application. The purpose of this book is to provide basic information about using and building these appliances. This book discusses specific applications, but does not contain sufficient information for a treatment plan for any specific condition.

Picture 1 shows a basic Radial Appliance with the wire and disk components essential for its attachment to the body. Although it looks like a battery, and was occasionally referred to as such in the readings, Edgar Cayce insisted that it produces no electrical energy of it own. He said that it acts more like a magnet that draws energy from one part of the body and redistributes it to other parts.

According to the readings, placing the appliance in a nonmetallic container full of ice water for about 20 minutes prior to attachment to the body chills the carbon steel core of the appliance. The steel core then becomes "electronized by ice or cold or water" (1800-4). Acting as a "radio magnet" (1800-28), the appliance can then affect the body's energy system when attached at definite anatomical centers on the surface of the body.

On the other hand, the Wet Cell (Picture 2) is definitely an electrochemical battery which produces a measurable direct current (DC) output. However, the strength of the battery is quite low. Typically, the battery produces a DC voltage of about 1/50 the output of a common 1.5 volt flashlight battery.

As with the Radial Appliance, Cayce said that the Wet Cell Battery works with the "low" form of electrical energy or life force of the body. The primary difference between the appliances is that the Wet Cell has a stronger effect on the body. Thus the Wet Cell is used almost exclusively as a "curative" treatment for chronic and degenerative diseases whereas the Radial Appliance is most often utilized as a "preventative" measure with "curative" applications at times.

In the "preventative" mode, the Radial appliance can be used as a tool for stress management and as an aid to meditation. Edgar Cayce said that it "would be good for EVERYBODY! ... This assists in keeping an EQUILIBRIUM. Not that it is a curative, but it is CERTAINLY a PREVENTATIVE!" (202-7). Used on a regular basis, the Radial Appliance can play an important role in a general health maintenance program.

The Wet Cell Battery is strictly a "curative" treatment. In other words, if the body is already seriously ill and in need of regeneration, the Wet Cell may be included as part of a comprehensive treatment plan. Cayce seldom prescribed it as the sole therapeutic modality. Physiotherapies including bodywork (such as massage and spinal adjustment), hydrotherapy, and diet were regarded as essential components in the integrated treatment plans recommended by Edgar Cayce. Cayce would also typically bring in the mental and spiritual aspects of healing when making referrals for the Wet Cell Battery. In certain cases, he said that treatment with the Wet Cell Battery should not begin until some progress in the spiritual area had been achieved (e.g., 3684-1, 4014-1, 4036-1, 5064-1).

The therapeutic possibilities of Cayce's comprehensive and integrated approach were enormous. The readings stated that remarkable physical healing could be expected, even with extreme illness. For example, in severe neurological disorders such as dementia, Cayce consistently maintained that the nervous system could be regenerated and that in some cases, the brain itself could be "rebuilt." A later section will discuss some of the therapeutic principles and techniques involved in nervous system regeneration.

With this brief introduction to the appliances, it is easy to see why the Radial Appliance and Wet Cell Battery were so much preferred by Edgar Cayce. They were regarded as relatively mild and safe and yet possessing tremendous therapeutic and preventative potential.

---

Picture 1: Radial Appliance in ceramic container with ice.

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Picture 2: Wet Cell Battery with solution jar and attachments. Modern Wet Cell Batteries are often made with plastic or synthetic containers.

A Report on a Research/Treatment Program Based on the Edgar Cayce Readings

http://www.meridianinstitute.com/msreport.htm

Multiple Sclerosis: A Complementary Medicine Approach A Report on a Research/Treatment Program Based on the Edgar Cayce Readings Meridian Institute June, 1997

Summary

Nine participants took part in a research project to explore the effectiveness of the Edgar Cayce treatment recommendations for multiple sclerosis. They spent 10 days in a live-in treatment and training program in September, 1996, then went home to continue the treatment protocol. Of the original nine, seven returned six months later in March, 1997, for a follow-up weekend to assess progress. Of the two who did not return, one person never began the protocol, due to illness immediately following the initial program. The other partially followed the protocol, reporting some success, but was unable to return for the follow-up. One of the seven people who did return had been unable to begin with the protocol until two months before the follow-up.

The treatment protocol included daily use of the wet cell electrical appliance with gold and Atomidine, massage, diet, and work with ideals, attitudes and emotions, meditation, and breathwork.

Physical symptoms were assessed both by physiological measurements of the autonomic nervous system (galvanic skin response and heart rate variability) and by subjective questionnaires. Mental/emotional/spiritual states were assessed by subjective questionnaires.

Subjects who followed the protocol consistently (but none completely or perfectly) averaged moderate improvement in MS symptoms over six months, on both subjective symptom checklists and questionnaires, and objective measurement of GSR. Three out of the seven reported major improvement. This rate of improvement was consistent with the typical Cayce prognosis. Continuation for a full year and attention to complete compliance with the protocol should produce even stronger results. This will require substantial logistic and emotional support for the patients.


Introduction

Multiple sclerosis is a disorder involving the inflammation and degeneration of the myelin (a fatty material that insulates nerves) in the brain and spinal cord. The loss of myelin is accompanied by a disruption in the ability of the nerves to conduct electrical impulses to and from the brain. This results in symptoms including balance and coordination problems, weakness (especially in the legs), visual disturbances, fatigue, bladder and bowel problems, and cognitive and emotional disturbances. In conventional medicine, multiple sclerosis is thought to be an "auto-immune" disease, in which the body attacks its own cells and tissues. Heredity, infectious, and environmental factors may all play a role.

The Edgar Cayce readings take a very different approach. They say that the primary cause of multiple sclerosis is a glandular imbalance, caused by improper assimilation of gold, and particularly involving the liver. The purpose of this research project was to explore the efficacy of Cayce's recommendations for treatment. It was a project in complementary medicine, meaning that it supplements conventional treatments, but was not intended to replace them. (Generally, however, the participants were not receiving specific treatment for MS, though some were receiving treatment for associated conditions such as depression.) The Cayce regimen is based primarily on diet, use of a low-voltage appliance known as the wet cell, and massage.

The project included the following components:

(1) Attendance at a 10 day, live-in program in Virginia Beach, with the following activities:

• an initial evaluation of multiple sclerosis symptoms, including thermographicphotography of the skin of the back and abdomen, and non-invasive measurements of autonomic nervous system functioning;
• introduction to the diet recommended by Cayce for treatment of multiple sclerosis, and following that diet during the program;
• spinal adjustments by a chiropractor;
• abdominal castor oil packs;
• massage and training in home massage by a massage therapist
• colonic irrigation by a colonic therapist;
• using a personal Cayce wet cell appliance;
• attending lectures on physical, psychological, and spiritual aspects of healing.

(2) Following a treatment program at home for 6 months, which included:

• daily adherence to the diet introduced at the program;
• regular use of the wet cell appliance followed by massage, according to the instructions given at the program;
• attention to the mental/spiritual aspects of healing;
• keeping a daily log of treatments and treatment-related events.

(3) Returning for a 3-day follow-up assessment after 6 months, which included:

• a repeat of the non-invasive autonomic nervous system assessments;
• filling out symptom and mental/emotional/spiritual questionnaires and evaluations;
• group discussions of treatment and support issues;
• planning for long-term treatment and support.

The Cayce Approach

Multiple sclerosis is one of the few diseases for which we have a Cayce reading given on the disease itself, for a doctor, rather than for an individual patient. Reading 907-1 states, "This condition of the spinal cord and of the brain is...the result of conditions which arise in the assimilating system from the lack of a balance in the hormones of the blood supply." It is described as produced by both, "an unbalanced diet and functional failure of the glands." Specifically, the glands involved are "those about the liver and the gall duct." In response to the question, what should be added, Cayce replied, "This depends on the progress of it... but, it is the effect of gold - the atomic effect of gold that should be added to the system." Cayce recommended that the gold be delivered "vibratorially," that is, with the wet cell battery, and also mentions silver and iron. Several of the MS readings given for individual patients also mention the importance of iodine for the glands. McMillin and Richards (1994) give details on the wet cell and its use with these solutions. Regarding diet, Cayce generally suggested a low-fat, high fresh vegetable, no fried food diet. For MS and other conditions requiring nerve rebuilding, the raw vegetables carrots, lettuce, celery and watercress were particularly recommended. The treatment protocol for this project is based on analysis of numerous Cayce readings for MS.

Notably in the MS readings, Cayce had a strong spiritual emphasis, and invoked karma as a causal factor. For example, "While we are working against karma, and there needs to be the renewing of faith in the divine, (the body once had it) we find that if the body will use what abilities it has to help others, there may be the quicker response..." (3626-1). Or, "In regard to the karmic condition...hence the first lesson spiritually is patience" (3779-1). Other spiritual advice included, "Add to the body first, then, brotherly love, patience, consistence; and whatever the disturbance, do not lose the sense of humor, but be patient. Do show brotherly love and kindness" (4005-1).

It is clear from the readings that healing MS is a long-term process. For example, "While the conditions may be aided, it will require patience, persistence and a great deal of determination on the part of the body and mind to attain to a control or a usefulness, or to use properly the limbs" (3695-1). Or, "As to whether there will be recuperative forces will depend a great deal upon how consistent and how persistent the body is in carrying out these applications...For...there has been an accumulation of almost a cycle, or five to six years of the general deterioration. To check and then build may require a complete cycle (seven years)" (3907-1)"

It was also clear, from reading the reports of many of the readings, that support for the patient is essential. It is likely that few people who received MS readings from Cayce actually carried out the treatments for the required length of time. One of our priorities was to make this material practical by focusing on support issues.

Although the Cayce approach is outside the mainstream medical perspective, there is some medical literature pointing to its possible validity in regard to the involvement both of gold and of the liver. There is very little literature on the role of gold in the human body. It is generally thought to be inert, although gold compounds have been useful for their anti-inflammatory properties in the treatment of arthritis. Only one researcher has explored the relationship of gold to pathology in the nervous system. El-Yazigi et al. (1984, 1990) looked at both silver and gold, as well as a variety of other trace elements, in cerebrospinal fluid of patients with cerebral neoplasms (brain tumors). (Silver is another important element in nervous system regeneration, according to Cayce.) The malignant tumor/control patient concentration ratio was 2.31 for silver. They state that the biochemical mechanism for this increased concentration is unknown. Although there was no consistent relationship between gold and tumor vs. control subjects, for the single patient with pinealblastoma the concentration of gold was about twice the concentration for the controls or other tumor types. The pineal has an important role in the Cayce model of the human system, so this is a relationship worth further exploration (e.g., see reading 3612-1, which mentions the pineal gland in connection with MS). El-Yazigi's group did not look specifically at MS patients. In personal correspondence with Douglas Richards (January, 1997), El-Yazigi stated that he was unaware of anyone else studying the role of gold in the nervous system, and was no longer pursuing this research himself.

There are also reports of involvement of the liver in MS. Taub et al. (1989), Noseworthy and Evers (1989) and Pontecorvo et al. (1992) all report co-morbidity of MS and primary biliary cirrhosis, a chronic disease with progressive destruction of the bile ducts in the liver leading to cirrhosis and, in some instance, progressive liver failure. The authors tend to see both the MS and the liver problems as results of an autoimmune process. But it is certainly possible that a problem in the liver is the cause of the MS, although in most people that problem may be subtle and not detected with current medical tests.

Methods

Subject Recruitment, Selection, and Informed Consent

MS subjects were recruited through announcements in Venture Inward magazine. Potential subjects were given medical history and information forms to fill out. From among the completed forms, Meridian Institute personnel selected those people deemed most likely to benefit from the project. Only adult subjects were allowed to participate; there are otherwise no restrictions on age, sex, or race. Nine participants were finally selected and attended.

Subjects were not financially compensated for participating in the study. All research and treatment costs were paid by the Barden/Beltone grant to the A.R.E. Conference costs related to housing, food, and transportation were paid by the subjects.

At the beginning of the conference, the project was explained in detail by the investigators, and the subjects signed informed consent forms. The forms emphasized that the project did not include discontinuation of any conventional therapy or medication. Subjects were informed that there are no known significant risks from proper application of castor oil packs, massage, or the wet cell and that there is a slight risk of some abdominal discomfort from colonic irrigations. Subjects were also informed that all subject medical records would be kept at Meridian Institute, under the supervision of Dr. Eric Mein, and that confidentiality would be protected according to accepted medical standards.

Assessment and Data Collection

The initial assessment and data collection took place the first morning of the conference. The goal was to establish a baseline for evaluation of treatment efficacy. The assessment included:

• Subjective symptom and lifestyle questionnaire
• Autonomic nervous system assessment
• Chiropractic assessment and thermographic photography
• Brief medical physical exam

The final assessment of subjective symptoms and lifestyle impacts was conducted 6 months later in a follow-up weekend.

Chiropractic and Thermographic Assessment

Dr. Carl Nelson conducted the chiropractic evaluation. Thermographic pictures were taken of the thoracic spine and abdomen with a Flexi-Therm liquid crystal thermographic camera.

Medical Examination

Dr. Eric Mein briefly evaluated the severity of the MS symptoms, confirming the subjective symptom questionnaire..

Subjective Symptom and Lifestyle Assessment

David McMillin administered questionnaires on symptoms and lifestyle, and conducted interviews to determine what other conditions might be co-existent with MS. The questionnaires can be divided into ones exploring MS symptoms and quality of life, and ones exploring mental/emotional/spiritual issues.

Symptom/Quality of Life Questionnaires

Symptom Checklist. This is a 26-item list of symptoms, with 5 response alternatives ranging from "None" to "Extreme." This questionnaire was filled out by the subject at the beginning of the project, at monthly intervals during home treatment, and at the follow-up weekend.

Activity Assessment. This is a 23-item list of activities, such as "Driving," "Shopping," "Having sex," and "Going to religious services." It is intended as a measure of quality of life, without regard to specific symptoms. There are 6 levels of response for each item, from "No limitation," to "Great limitation." The score is a sum of the responses, from a low of 0 (no limitation on any activity) to 115 (great limitation on all activities). This questionnaire was filled out by the subject at the beginning of the project, at monthly intervals during home treatment, and at the follow-up weekend.

Daily Functioning Assessment. This is an 11-item questionnaire which is intended to assess the impact of the disease on daily functioning. It has items such as "My ability to write and/or speak...," and "My ability to think clearly and remember things...," with response choices such as "is unaffected," and "is moderately affected." There is also a single item at the end, "Since beginning the Cayce therapy regimen, I feel my symptoms...," with response alternatives such as "are very much improved," and "are very much worse." Possible scores on this scale range from 11 (no functioning affected) to 47 (all functioning strongly affected). This questionnaire was filled out by the subject at the beginning of the project, at monthly intervals during home treatment, and at the follow-up weekend.

Assessment of Medication Side Effects. This is a 21-item list of typical side effects of medications used to treat neurological and psychological disorders. There are 6 levels of response for each item, ranging from "None, to "Very severe." The score is a sum of the responses, from a low of 0 (no side effects) to 105 (many very severe side effects). This questionnaire was filled out by the subject at the beginning of the project, at monthly intervals during home treatment, and at the follow-up weekend.

Mental/Emotional/Spiritual Questionnaires

Attitudes and Emotions Assessment. This is a 15-item questionnaire based on issues often raised by Edgar Cayce, developed by David McMillin. It has items such as "I am a very cooperative person, " and "I find it difficult to trust people." Possible scores range from 15 (very negative attitudes) to 60 (very positive attitudes). This questionnaire was filled out at the beginning of the project, at monthly intervals during home treatment, and at the follow-up weekend. It was filled out by the subject for him/her self, and by the support person to independently rate the subject.

Beck Depression Inventory. This is the standard assessment of depression symptoms developed by Beck et al. (1961). It has 21 items, such as "I feel blue or sad," and "I cry more than I used to." Possible scores range from 0 (no symptoms of depression) to around 70 (more than one response level can be marked for some items, but for others only one would typically be marked). This questionnaire was filled out at the beginning of the project, at monthly intervals during home treatment, and at the follow-up weekend, by both the subject and the support person.

Spiritual Well-Being Scale. This is a 20-item assessment of "spiritual well-being." (Paloutzian & Ellison, 1982; Ellison & Smith, 1991). The items are of 2 types. One type looks at general ("existential") well being and sense of purpose, e.g., "I feel that life is a positive experience," or "Life doesn't have much meaning." The other type assesses religious well-being, based on a Christian concept of relationship to God, e.g., "I have a personally meaningful relationship to God." Possible scores range from 20 (meaningless life) to 120 (high existential and spiritual well-being). Ellison & Smith cite positive correlations between this scale and physical well-being and positive adjustment to physical illness. This questionnaire was filled out at the beginning of the project, at monthly intervals during home treatment, and at the follow-up weekend, by both the subject and the support person.

Index of Spiritual Experience. This is a 7-item questionnaire concerning spiritual practices, beliefs and experiences (Kass et al., 1991). Since the questions tap a diversity of spiritual aspects, we did not combine the items into a single score. When scored according to the Kass et al. system, all our subjects scored in a high, narrow range of spiritual experience. To further discriminate the intensity/diversity of experiences, we have added together the responses to the seventh question, which is a checklist of 13 possible spiritual experiences on a 1 to 4 scale of how much they have strengthened belief in God, for a low score of 13 (no spiritual experiences) to a high score of 52 (all profound spiritual experiences). This questionnaire was filled out at the beginning of the project, at monthly intervals during home treatment, and at the follow-up weekend, by both the subject and the support person.

Healing Questionnaire. This is a 6-item questionnaire developed by David McMillin, covering the 6 forms of healing discussed by Wayne Jonas and others (Schneider, 1994). They include cure, care, quality of life, empowerment, enlightenment, and soul development. It was used to evaluate the priority assigned by each subject to each of the six forms of healing, and the degree to which they felt that each form of healing was occurring. The ratings are not intended to be combined into a single scale.

Autonomic Nervous System Assessment

Several aspects of autonomic nervous system functioning were assessed by Douglas Richards using computerized equipment (Biopac Instruments MPS100). We measured heart rate with an ECG, finger and toe pulse with a photoplethysmograph, skin conductance (galvanic skin response), breathing, and finger temperature (see protocol, Appendix B). Our goal was to explore the forms of nervous system incoordination present in multiple sclerosis. We expected abnormalities in both heart rate variability and in galvanic skin response, based on the MS literature (e.g., Caminero et al., 1995; Drory et al., 1995; Elie & Louboutin, 1995).

Home Treatment Protocol and Monitoring

The initial conference was a training experience to enable participants to carry out the treatments at home. A notebook was provided with detailed instructions for home treatment, with a single page summary treatment protocol (Appendix A). Log sheets (Appendix C) were provided for recording compliance with the protocol, changes in symptoms, and any adverse effects. During the course of home treatment, subjects were asked to submit their progress logs on a monthly basis. It was emphasized to the subjects that they should not modify their current medical treatments for their condition, including medications, without specifically consulting their physicians. Any such modifications were to be noted in the daily logs.

Results and Discussion

Initial Assessment

Analysis of questionnaires and physiological measurements

The symptom and quality of life questionnaires, together with the physical exams, revealed a wide range of disability. Similarly, the mental/emotional/spiritual questionnaires varied widely as well. Table 1 gives the questionnaire results and Table 2 gives the correlations among the questionnaires. These are most useful for seeing general patterns, since the small sample size (9) means that a very high correlation is needed for statistical significance. The various questionnaires measured similar aspects of the effects of MS, but the correlations among the scores show that they were not measuring identical effects.

Thermographic assessment revealed consistent "hot spots" over the 6th and 7th thoracic spine centers in each of the subjects. This finding may be relevant to upper digestive system dysfunction (i.e., liver/gall bladder/gall duct). Consistent with this finding was the presence of a "cold spot" in the upper right abdominal quadrant.

Galvanic skin response and heart rate variability were the two autonomic system measurements expected to correlate with MS symptoms. Galvanic skin response (as measured by summing the baseline skin conductance and the responses to 4 autonomic tests) was rather low in most of the subjects, and virtually absent in four of the subjects with severe MS symptoms. This result is consistent with that of many other MS researchers, e.g., Caminero et al. (1995), who said, "SSR [Sympathetic skin response, a similar measurement to GSR] is a simple test for a dynamic evaluation of MS, well correlated with the degree of disability." Table 3 gives the means and standard deviations for the GSR and heart rate variability measurements (HRV). The GSR report gives the baseline, the responses to the 4 autonomic tests, and the sum of these measurements (in microsiemens). The HRV report gives the range of heart rate during deep breathing at 6 breaths per minute, and the ratio of spectral power (from an FFT) at .1 and .2 Hz) during deep breathing at 6 breaths per minute and 12 breaths per minute. The latter two measurements are intended to show sympathetic and parasympathetic activity, respectively. Table 4 gives the correlations of GSR and HRV with the subjective questionnaires. Many of the correlations of these autonomic variables with symptoms are not significant, due to the small sample size. Nevertheless, patterns are apparent, e.g., a clear cluster of high correlations of HRV with most of the questionnaires, and of GSR with Spiritual Well Being and Daily Functioning.

Follow-up Assessment

Progress from daily log sheets

Log sheets of compliance with the treatment protocol and subjective perception of improvement were submitted by the subjects at monthly intervals. Figure 1 graphs the perceived improvement in symptoms for the six subjects who consistently followed the protocol over the six months. The trend is clearly upward, but it is also apparent that in some people several months of following the treatments are necessary before significant improvement is noticed.

Analysis of questionnaires and physiological measurements

Summary Questionnaire. The summary questionnaire asked the subjects to rate their compliance with the various elements of the protocol, and then to rate the changes in their MS symptoms and in their attitudes and emotions. All subjects reported roughly the same level of compliance ("most of the time"). Wet cell compliance was consistent, but subjects varied widely in their ability to obtain the post-wet-cell massage. Some had continually available support, while others had no support at all and had to try self-massages or did not do massages. Subjects rated improvement on a 7-point scale, with 1=much improvement, 4=no change, and 7=much worse. All subjects reported some improvement, both in attitudes/emotions and in MS symptoms. The average score for MS symptom improvement was 2, "moderately improved." Three out of the 7 were "much improved." For attitudes/emotions improvement, the average score was also 2, "moderately improved." Two of the 7 were "much improved." All had at least slight improvement.

Follow-up Questionnaires and Physiological Measurements. Table 5 gives the results of the follow-up questionnaires. Note that the questionnaires for support people are not included because only 2 support people attended both the baseline and follow-up parts of the project. Table 6 gives the results of the follow-up physiological measurements. Table 7 gives the correlations among the follow-up questionnaires. The pattern - that the questionnaires are all measuring somewhat different aspects of MS - is similar to that of the baseline questionnaires. Table 8 gives the correlations of the follow-up questionnaires with the physiological measurements. The pattern is again similar to the baseline - there is a cluster of high correlations with HRV, and Daily Functioning has a relatively high correlation with GSR. Due the small sample size (6), not much meaning should be attached to the exact numerical values of the correlations.

Before/After Comparison of Questionnaires. The improvements documented in the summary questionnaire were also reflected in the individual questionnaires on both symptoms and attitudes/emotions. The difference in these two types of measurements is that the summary questionnaire required a retrospective comparison with the baseline 6 months previously. The before/after comparison was a simple subtraction of the numerical scores on the same questionnaires administered at the baseline and follow-up. Thus, no memory for the previous symptoms was required. The symptom checklist, activity assessment, daily functioning assessment, Beck depression inventory, and spiritual well-being scale all showed improvements. The very small sample size (6 subjects) makes statistical tests difficult to interpret (i.e., only extremely strong relationships would reach statistical significance). The attitudes and emotions assessment and the number of spiritual experiences did not change. The attitudes and emotions assessment questions are similar to those used in social desirability scales, and the lack of change may reflect more a stability in the response set for socially desirable items. See Table 9. The GSR and HRV measurements show only very slight (and statistically non-significant) changes (Table 10). Very interesting, however, are the correlations of the changes in GSR and HRV with the changes in the subjective questionnaires. There were a number of strong correlations, particularly with HRV and with the GSR baseline.

Overall, then, despite the difficulty of obtaining statistical significance with only 6 subjects, there are patterns that suggest changes in GSR and HRV are related to changes in subjective assessment of both symptoms and mental/emotional/spiritual states.

Personal experiences from interviews and questionnaires

At the six-month stage of the project, the most interesting results are not from the questionnaires or statistical analysis, but from the written comments and personal interviews with the participants. They were all very positive about the project itself, but some had to grapple with major personal issues. As discussed in the Introduction, Cayce saw MS as a condition in which much karma was involved. Translated into practical terms, this means that major mental/emotional/spiritual issues in relationships are prominent in the disease and in the response to treatment.

Here are some example of comments and observations. More complete case studies of the individuals are also available.

D.A.: "I am strengthening and healing, slowly and steadily. I cannot say that there are many noticeable effects yet to the outside world; I still stumble, lose balance, and move awkwardly sometimes, for instance. But I feel a whole lot stronger and better. I figure the nerves and muscles will catch up with me shortly....I am noticing some very pleasant "minor" changes...I am taking fewer and shorter naps lately (no longer the 3-4 hour daily requirements they once were). I look rested and my skin coloring is not as splotchy. [My husband] has noticed this. I feel more motivated (I've begun taking some home repair projects and am developing a list for the future). Last week while doing some raking, I even perspired (who would have thought that I'd be pleased to mop my brow, but it means I am regaining more normal reactions. I was so happy!). These may not be big changes to some, but I'm pleased as punch."

Conclusions

In the six-month period covered by this report, there was a substantial improvement in subjective MS symptoms and in attitudes/emotions, correlated with autonomic measurements. This result is impressive, since the Cayce readings and some anecdotal reports from people with MS who have applied them, suggest that the healing of this disease is a very long-term process.

The physical therapies - diet, the wet cell, massage - are straightforward, but require "consistency and persistency," as the Cayce readings would say. There is a great need for a reliable support person or network for success with this program. With MS, the emotional issues often complicate the support situation, although there are great opportunities for personal growth.

References

Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry, 4, 561-571.

Caminero, A. B., Perez-Jimenez, A., Barreiro, P., & Ferrer, T. (1995). Sympathetic skin response: correlation with autonomic and somatic involvement in multiple sclerosis. Electromygr. Clin. Neurophysiol., 35(8), 457-462.

Drory, V. E., Nisipeanu, P. F., & Kroczyn, A. D. (1995). Tests of autonomic dysfunction in patients with multiple sclerosis. Acta Neurol. Scand., 92(5), 351-360.

Elie, B., & Louboutin, J. P. (1995). Sympathetic skin response (SSR) is abnormal in multiple sclerosis. Muscle Nerve, 18(2), 185-189.

Ellison, C. W., & Smith, J. (1991). Toward an integrative measure of health and well-being. Journal of Psychology and Theology, 19, 35-48.

El-Yazigi, A., Al-Saleh, I., & Al-Mefty, O. (1984). Concentrations of Ag, Au, Bi, Cd, Cu, Pb, Sb, and Se in cerebrospinal fluid of patients with cerebral neoplasms. Clinical Chemistry, 30, 1358-1360.

Kass, J. D., Friedman, R., Leserman, J., Zuttermeister, P. C., & Benson, H. (1991). Health outcomes and a new index of spiritual experience. Journal for the Scientific Study of Religion, 30, 203-211.

Macy, J. A., Gilroy, J., & Perrin, J. C. (1991). Hereditary coproporphyria: An imitator of multiple sclerosis. Arch. Phys. Med. Rehabil., 72, 703-704.

Noseworthy, J. H., & Ebers, G. C. (1989). Primary biliary cirrhosis and multiple sclerosis. American Journal of Gastroenterology, 84(12), 1584-1585.

Paloutzian, R. F., & Ellison, C. W. (1982). Loneliness, spiritual well-being, and the quality of life. In L. A. Peplau, & Perlman, D. (Eds.), Loneliness: A sourcebook of current theory, research and therapy. New York: Wiley.

Pontecorvo, M. J., Levinson, J. D., & Roth, J. A. (1992). A patient with primary biliary cirrhosis and multiple sclerosis. American Journal of Medicine, 92, 433-436.

Schneider, C. J. (1994). Are alternative treatments effective? Issues and methods involved in measuring effectiveness of alternative treatments. Presidential address at the 4th annual conference of the International Society for the Study of Subtle Energies and Energy Medicine, Boulder, Colorado.

Taub, W. H., Lederman, R. J., Tuthill, R. J., & Falk, G. W. (1989). Primary biliary cirrhosis in a patient with multiple sclerosis. American Journal of Gastroenterology, 84(4), 415-417.

Goat Serum Helps MS Sufferers Walk Again

PATIENTS suffering from multiple sclerosis (MS), the incurable wasting disease, have experienced dramatic improvements in their condition after taking part in trials of a drug derived from goat serum.

Some have reported being able to cast aside their walking sticks and walk for miles, or of regaining their vision or finding they can again use their limbs after years when any movement was agony. Of the 130 patients on the trial, 85% reported big improvements with no side effects.

Among them is Billy Edmiston, of Southsea, who was diagnosed with MS in 1988. “At the time of my first injections 15 months ago I was using walking sticks and sometimes a wheelchair. I started this treatment with no expectations but it has been astonishing,” he said.

“I am 500% better than I was. I can walk for several miles without sticks. I’m much stronger and generally healthier. And you have to remember that we have always been told that there may be remissions, but that the progress of the disease is unstoppable.”

The success of the trials has started to gain international recognition with Alan Osmond, one of America’s leading campaigners about the disease, travelling from the US to take the drug.

Osmond, the eldest member of the Osmonds singing group, who was diagnosed with the disease 17 years ago, said: “When I heard about the treatment here I decided I would have to come and see for myself.”

MS is the most common chronic disease of the central nervous system in young adults, affecting millions of people worldwide. Most cases are diagnosed between the ages of 20 and 40 and famous sufferers include the cellist Jacqueline du Pré, the actor Richard Pryor, director Bryan Forbes and Tory whip David Maclean.

An often progressive disease of the central nervous system, MS occurs in the brain, the optic nerves and the spinal cord. Though slow in its onset, in time it may produce tremors, partial loss of sight and paralysis.

The new treatment is being pioneered by a team of scientists and doctors led by Professor Angus Dalgleish, an oncologist based at St George’s hospital, Tooting, south London, who believes it will at worst provide a highly effective subjective treatment for MS sufferers, but may lead to a long-term improvement.

The treatment, given as a weekly injection, is derived from purified serum from immunised goats that produce antibodies. Three separate clinical trials are now being conducted.

Normally it would have taken about eight years and about £80m to get a new product to this stage. In this case it has been achieved in three years, having cost so far about £5m.

Dr David Maizels, a family doctor from Chiselhurst in Kent who had been treating patients in the “informed consent” trials for the past three years, said he had never seen anything like it.

“I want to emphasise that this is not a placebo effect. The improvements are sustained and there are almost no side effects. At times the results are amazing,” he said.

The trials, the first of which should be completed and analysed by the spring, will confirm whether there will be new hope for MS sufferers worldwide.

“Being positive is the key thing,” said Osmond. “It’s not the disease that beats you, but the lack of hope.”

Original Article can be found here (subscription required)

Note: One of our user''''s submitted the following info from this website:

"Caprivax. Whilst searching for new anti inflammatory agents we found surprising activity in the serum from certain inoculated goats. The nature of the anti inflammatory component of the serum was thought to be potentially useful in the treatment of multiple sclerosis and a pilot study suggested this may be the case. A formalised trial has now been submitted for patients with secondary progressive multiple sclerosis under Dr David Barnes at the Atkinson Morley''''s Hospital at Wimbledon."

and the Financial Times had this to say:

"The drug has strong anti-inflammatory properties which might make it effective against MS. Tests on patients have so far produced promising results, with a noticeable improvement in symptoms with no adverse side-effects. However, the benefits could be the result of the placebo effect. During the current trial, involving 80 patients, half will be given a weekly injection of Caprivax and half will receive a placebo. They will be assessed regularly for changes in muscle stiffness, mobility and vision."

Looks legitimate, folks... stay tuned.

Aimspro (Goat Serum) Update

Daval’s mission is to make "Aimspro'" available to all those who wish to take advantage of its therapeutic properties, as quickly as possible.

To attain this goal we need to achieve certain clinical, regulatory and commercial objectives which I am confident we are on course to do. The first is in our own hands and those of our eminent team of scientists. Increasing vocal patient demand will add weight to our regulatory submissions, and a projected partnership with a larger marketing organisation will assist in attaining the third objective.

As so many friends of Daval are aware, Aimspro is particularly suited to the treatment of neural disorders, such as multiple sclerosis, although we are becoming increasingly impressed with its applicability to other disorders of an inflammatory nature. The 150 patients who are already receiving Aimspro on an informed consent basis all attest to its efficacy. Daval is confident that those receiving it on the authorised trials currently taking place in this country will provide a similar endorsement in due course. We are keeping the appropriate government departments regularly apprised of the development of our remarkable medication in anticipation that they will help Daval to fast track its general availability.

We feel it would certainly be in their interest to do so as we are already achieving significant savings for the National Health Service by freely treating patients. When the product's true potential is fully realised these savings would amount to many, many millions of pounds. This would also be consistent with the Government’s frequently stated intention of strongly supporting the British bio-technology industry.

Daval has a growing number of supporters who are assisting its progress with their varied skills and the Board is most grateful for their continuing encouragement during this crucial development period.”

Brian Quick. July 2004

17/03/08 - Decision on Terminated Clinical Trial

The Board of Daval International Limited decided, in 2004, to terminate the first full-scale clinical trial of AIMSPRO at St George's Hospital, London. The Company had drawn on a broad range of Medical and Pharmaceutical opinion to form this important decision, which was necessitated by the sub-standard handling of trial medication at the hospital's pharmacy, with the possible risk to patient safety and data integrity. A complaint against the responsible hospital pharmacist was then lodged by Daval with the Royal Pharmaceutical Society of Great Britain.

The allegations of misconduct against the pharmacist were considered by the Investigating Committee on 4th March 2008 and it's judgement fully vindicates Daval's action in discontinuing this study, which was a two year placebo-controlled, double blind study of AIMSPRO as a potential palliative medication for Secondary Progressive Multiple Sclerosis.

The Committee reasoned that there were a number of factors and areas of responsibility which contributed to the failure of the clinical trial and that the pharmacist had failed to take control of his responsibilities by ensuring that appropriate standard operating procedures were in place.

Although this matter has taken some time to be resolved, Daval is pleased that the accusations which have been circulated by malicious and irresponsible parties since 2004, regarding the Company's motives in terminating the trial, have been satisfactorily quashed. As regards future human studies, Daval's interests are somewhat protected by the tighter Clinical Trial regulations in the United States, Europe and Australia that are now in force. It is re-stated that the company's over-riding priority, as it passes through the development phase of AIMSPRO, a complex biological medication, will be that of patient safety.

Daval adheres to the Code of Practice of the ABPI, of which it is a member.

Daval International Limited

More infos : http://www.davalinternational.com/

Amalgam + MS

MS is the disease that has most often come to our attention. It is a disease in which the immune system attacks the myelin, or insulation around nerves. Historically there are many references to suspicion between Amalgam and MS. From the biological standpoint mercury can attack myelin tissues and generate an autoimmune response. Mercury can also alter the 3-dimensional form of proteins that can lead to the inhibition of catalytic activity that may be necessary in nerve impulse transmission.
Mercury damages the protective abilities of the blood-brain barrier that select what can and cannot cross into the brain, thus indirectly allowing other harmful substances to enter nervous tissue. Published scientific articles by Arvidson describe how mercury can leave the filling, go through the pulp chamber onto the nerve that activates the teeth -- the trigeminal nerve -- and follow this nerve backward (retrograde transport) into the brain. A Swedish researcher, Nylander authored one of several papers describing the close correlation between the amount of mercury in the brain of cadavers and the number of amalgam fillings present.

From results of a survey on a radio show, it was noted that mercury is not the only dental material that can stimulate MS. When asked, "If you have come down with an incurable or non-responsive disease and had dental work done within 6 months before the onset, what was the dental procedure, and what was the disease, and how long was it in between. You will have 20 seconds to tell this information." Six lines were lit up continually for the next hour and a half. The winner? Multiple sclerosis diagnosed by MRI within 90 days after the placement of a root canal.

That was a surprise, but now that we have studied root canals more, it seems far more plausible. Toxins found on extracted root canal teeth have been noted to kill some of the body's most resistant enzymes at extremely minute dosages. This contributes damaged nerve impulse transmission and to a reduction of immune defense. If these chemicals touch cells and does not kill them, they do not look like self, and therefore can stimulate an autoimmune response.

In a system I call "new math", it is noted that if a toxicity of one kind is introduced to a biological system, it has X potential for damage. If another toxin of 1 X potential is added to it, the total is not one, not two, but may be 50 times more damaging than either one by itself. In the oral cavity, it is not unusual to find Amalgams with 5 metals that produce 16 corrosion products, a root canal tooth filled with more than 10 chemicals that also produce a whole new gamut of toxins, a crown made from 6 or more non-precious metals, together with a plastic composite filling containing up to 8 chemicals. 1+1+1= what, in a conglomerate like this?

Removal of amalgam, root canals, and other offending substances from the mouths of MS patients when done according to a certain protocol has produced remarkable results in hundreds of MS patients. Not only have their motor skills improved, but blood chemistries and even protein degradation in the cerebro spinal fluid have improved. Why have the ADA and MS society banned together to prevent this information from getting to the public?

Thérapie à l’oxygène hyperbare pour les troubles neurologiques

Sclérose en plaques
La sclérose en plaques est une maladie chronique, récurrente et progressive a associé avec les lésions du système nerveux et est maintenant croit pour être une maladie incendiaire. En raison des divers signes et le cadre de symptômes et temps entre les assauts initiaux il est parti parfois non traité pendant des années. Un cours de traitement devrait être commencé aussitôt qu'un malade est diagnostiqué avec un régulier donne suite à des traitements comme nécessaire. Les traitements d'oxygène de Hyperbaric ont montré une réponse favorable surtout dans les malades avec moins d'étapes avancé de la maladie.

http://www.hbotxofpalmbeach.com/abstracts_study.html


Contenu du fichier PDF :

Hyperbaric Oxygen Therapy for Multiple Sclerosis Patients

Reports from four countries describing benefits from hyperbaric oxygen Therapy (HBOT) in the 1970's led to the
first controlled trial conducted at New York University which was published in the New England Journal of Medicine
in 1983. The outcome was very positive (p<0.0001),1 despite choosing chronic progressive or stable patients with a
minimum disease duration of over 11 years.
The patients were matched and randomly allocated to treatment or control groups and examinations were
conducted before, during and after a course of treatment by masked observers. The authors indicated that further
studies using longer follow-up periods were necessary as were studies of the use of oxygen treatment in patients
with acute symptoms. The second trial, published in the Lancet in 1985 also recruited chronic patients with disease
duration in excess of ten years. It demonstrated statistically significant improvement in bladder function. (p< 0.03)
(2) The final report of this study found that at the end of a year of follow-up there was less deterioration of
cerebellar function in the treated group.(3)
The improvement in bladder function after a course of twenty sessions generally lasted for six months. These
authors also suggested that further studies should be undertaken. In 1986 a London group published a preliminary
report in the British Medical Journal. (4) Positive effects were again reported for bladder function and several other
symptoms. In 1988 Oriani et al (5) used patients with a low disability score and compared 22 controls with 22
patients treated every week for a year. They detected an appreciable difference in outcome (p < 0.01) and
confirmed the effect using evoked potential measurements. In 1986 Pallotta et al 6 published a follow-up of 22
patients over 8 years. All received an initial course of 20 HBO treatments, and 11 were treated thereafter with 2
exposures every 20 days. The frequency of relapses decreased dramatically in the prolonged treatment group
whereas they gradually increased in the group which received only an initial course of treatment. Oxygen delivered
under hyperbaric conditions is the only agent to have resulted in improvement in patients with chronic progressive
and chronic stable MS.
The Multiple Sclerosis Treatment Centers, which are A UK Charity, provide HBO therapy in 62 Centers. Note that
the MS Society does not endorse any treatment for Multiple Sclerosis but "is not hostile to HBO and does not
regard it as dangerous or expensive". The outcome of treatment in 703 patients followed for 10 or more years has
been studied. Comparison of the results with published data on the natural history of MS shows a significant
reduction in the rate of deterioration which is related to the frequency of treatment (7). The need for continuation
therapy is now accepted as with the use of beta interferon. The possibility of preventing sclerosis by treatment
during acute attacks has still to be addressed. Lactate, a marker of oxygen deficiency, can be seen in acute MS
lesions using magnetic resonance spectroscopy. This shows the need for urgent administration of oxygen and
there is no substitute.
1. Fischer BH, Marks M, Reich T. (1983) Hyperbaric-oxygen treatment of multiple sclerosis: A randomized,
placebo-controlled, double-blind study. N Engl J Med; 308:181-6.
2. Barnes MP, Bates D, Cartlidge NEF et al (1985) Hyperbaric oxygen and multiple sclerosis: short term
results of a placebo-controlled, double-blind trial. Lancet ii:297-300.
3. Barnes MP, Bates D, Cartlidge NEF et al (1987) Hyperbaric oxygen and multiple sclerosis: final results of a
placebo-controlled, double-blind study. J Neurol Neurosurg Psychiatry 50: 1402-1406.
4. Wiles CM, Clarke CRA, Irwin HP et al (1986) Hyperbaric oxygen in multiple sclerosis: a double blind study.
Br Med J 292:367-371
5. Oriani G, Barbieri S, Pirovano C, Mariani C (1987) Hyperbaric oxygen in chronic progressive multiple
sclerosis : a placebo-controlled, double-blind, randomised study with evoked potentials evaluation. In:
Oriani G (ed) Proceedings of the thirteenth annual meeting of the European Undersea Biomedical Society.
Palermo: European Undersea Biomedical Society: 196-203.
6. Pallotta R, Longobardi G, Fabbrocini G (1986) Experience in protracted follow-up on a group of multiple
sclerosis patients periodically treated with hyperbaric oxygen therapy. In Baixe J-H (ed). Symposium sur le
traitment de la sclerose multiple par l'oxygene hyperbare. Paris.
7. Perrins DJD, James PB.(1994) The treatment of Multiple Sclerosis with prolonged courses of hyperbaric
oxygen. Proceedings of the 1st European Consensus Conference on Hyperbaric Medicine. Lille : 245-263.